A. Sharma

Phylogenetically distant enzymes localized in cytosol and plastids drive citral biosynthesis in lemongrass

This study identifies two phylogenetically distant enzymes, CfADH1 and CfAKR2b, localized in cytosol and plastids, that drive citral biosynthesis in lemongrass.

Gut and oral microbial community characterization from women with breast cancer, women with ductal carcinoma in situ, and healthy women reveals differences in gut but not oral microbiota

This study compares gut and oral microbiota in women with breast cancer, ductal carcinoma in situ, and healthy controls, finding significant gut microbiota differences but not oral ones.

Asparagine couples group A Streptococcal metabolism to virulence

This study shows that asparagine (Asn) availability regulates Streptococcus pyogenes virulence and metabolism by controlling intracellular ATP levels and CovR/S signaling.

Hedgehog-Hippo pathway interactions promote T cell exclusion from the tumor microenvironment in basal cell carcinoma

This study shows that HH/GLI and Hippo/YAP pathway interactions suppress T cell chemotaxis and promote immunosuppression in BCC by downregulating chemokine signaling.

Understanding Cu binding with DNA: A molecular dynamics study comparing Cu and Mg binding to the Dickerson DNA

This study uses molecular dynamics to compare Cu2+ and Mg2+ binding to Dickerson DNA, revealing similar binding preferences but distinct binding mechanisms for Cu2+.

Active fluctuations of axoneme oscillations scale with number of dynein motors

The paper quantifies phase fluctuations in axonemes after dynein motor removal, showing increased oscillation precision with motor number and distinct roles for inner and outer arm dyneins.

The C-terminal regulatory domain of IPMS enzyme maintains leucine homeostasis by bypassing a hidden negative feedback loop in plants

This study shows that removing the C-terminal regulatory domain of IPMS in plants disrupts leucine homeostasis by enabling pathway intermediates to inhibit IPMS activity.

Combining multiple stressors unexpectedly blocks bacterial migration and growth

The paper shows that combining physical and chemical stressors significantly reduces bacterial growth and migration, contradicting previous studies that used single stressors.

Deep phenotyping of the prostate tumor microenvironment reveals molecular stratifiers of relapse and links inflammatory chemokine expression to aberrant metabolism

The paper identifies molecular signatures in prostate cancer that link inflammatory chemokine expression to metabolic changes and relapse risk.

Fluid flow overcomes antimicrobial resistance by boosting delivery

This study shows that fluid flow enhances antimicrobial delivery to overcome resistance in Pseudomonas aeruginosa by outcompeting bacterial neutralization mechanisms.

Impact of Species-Specific Plant Growth-Promoting Rhizobacteria (PGPR) on Maize (Zea mays) Phenotypic and Biochemical Diversity

This study evaluates the impact of four PGPR species on maize growth and biochemical parameters, finding significant increases in chlorophyll, enzymes, and yield.

Xanthomonas protegens sp. nov., a rice seed-associated probiotic and taxonomic outlier species of Xanthomonas sontii

The paper isolates and characterizes a new non-pathogenic Xanthomonas species, X. protegens, from rice seeds and highlights its probiotic properties and taxonomic distinctiveness.

Lecanemab Blocks the Effects of the Aβ/Fibrinogen Complex on Blood Clots and Synapse Toxicity in Organotypic Culture

This study shows lecanemab blocks Aβ/fibrinogen complex formation, reducing clot abnormalities and synaptotoxicity in AD models.

Arabidopsis ubiquitin ligase PUB41 is a positive regulator of the ABA response

This study identifies AtPUB41 as a positive regulator of ABA signaling in Arabidopsis, affecting seed dormancy, germination, and drought resilience.

Guava cv. Allahabad Safeda Chromosome scale assembly and comparative genomics decodes breeder choice marker trait association for pink pulp colour

The paper presents a chromosome-scale guava genome assembly and identifies a gene associated with pink pulp color through comparative genomics and marker-trait association analysis.

Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer.

The paper identifies a G-quadruplex in the ORAI1 promoter that regulates transcription and Ca2+ dynamics in triple-negative breast cancer.

Immunosuppression in the prostate tumor microenvironment is tied to androgen deprivation therapy-resistant club-like cells

The paper identifies club-like cells in the prostate tumor microenvironment that contribute to androgen deprivation therapy resistance through immune suppression.

Diversification of an emerging bacterial plant pathogen; insights from the global spread of Xanthomonas euvesicatoria pv. perforans

This study analyzes the global genetic diversity and evolution of Xanthomonas euvesicatoria pv. perforans, revealing population structure and effector gene variation linked to its spread as a tomato pathogen.

Modulation of SARS-CoV-2 spike binding to ACE2 throughconformational selection

This study uses single-molecule techniques to show that SARS-CoV-2 spike protein RBD dynamics modulate ACE2 binding through conformational selection without affecting unbinding.

The Role of Ebola Virus VP24 Nuclear Trafficking Signals in Infectious Particle Production

This study demonstrates that Ebola virus VP24 undergoes nuclear trafficking via IMPA and its nuclear export signal (NES) is critical for nucleocapsid formation and infectivity.

A multi-modal image fusion workflow incorporating MALDI imaging mass spectrometry and microscopy for the study of small pharmaceutical compounds

This paper presents a multi-modal image fusion workflow combining MALDI imaging mass spectrometry with microscopy to improve spatial resolution and co-registration of pharmaceutical compound and receptor data.

DR5 disulfide bonding as a sensor and effector of protein folding stress

This study shows that disrupting DR5 disulfide bonds activates pro-apoptotic signaling and reveals DR5 disulfide bonding as a sensor and effector of ER stress in cancer cells.

Deep learning methods to forecasting human embryo development in time-lapse videos

This paper introduces an AI system that forecasts future embryo morphology in time-lapse videos using Convolutional LSTM layers, showing accurate predictions for cleavage and blastocyst stages.

Bicyclic pyrrolidine inhibitors of Toxoplasma gondii phenylalanine t-RNA synthetase with antiparasitic potency in vitro and brain exposure

This paper describes new bicyclic pyrrolidine inhibitors of Toxoplasma gondii PheRS with improved potency, selectivity, and brain exposure compared to previous azetidine-based inhibitors.

miR858a-encoded peptide, miPEP858a, interacts with miR858a promoter and requires C-terminus for the associated functions

The paper identifies the C-terminal region of miPEP858a as essential for its interaction with the MIR858 promoter and its regulatory role in miR858a expression and plant development.

A biodegradable microgrooved and tissue mechanocompatible citrate-based scaffold improves bladder tissue regeneration

This paper develops a biodegradable scaffold that enhances bladder tissue regeneration in rats by incorporating microgrooves and stem cells, improving bladder function and structure.

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

A shade-responsive microprotein in ATHB2 regulates Arabidopsis growth and root development

The paper identifies a microprotein from ATHB2 that regulates Arabidopsis growth and root development by modulating DNA-binding activity and light responses.

Orphan nuclear receptor NR2E3 and its small-molecule agonist induce cancer cell apoptosis through regulating p53, IFNα and MYC pathways

This study shows NR2E3 activates p53 and induces apoptosis in cancer cells, with its agonist 11a synergizing with Romidepsin to suppress cervical cancer through multiple molecular mechanisms.

Role of Dusp5 KO on Vascular Properties of Middle Cerebral Artery in Rats

This study examines the structural and mechanical properties of the middle cerebral artery in Dusp5 KO rats, finding limited structural changes but enhanced myogenic tone, suggesting Dusp5's role in hemodynamics and cognition is enzyme-driven.