A complete allosteric map of a GTPase switch in its native network
C. J. P. Mathy, P. Mishra, J. M. Flynn, T. Perica, D. Mavor, D. N. A. Bolon, T. Kortemme
The paper systematically identifies new allosteric regulatory sites in Gsp1/Ran by mutational scanning, revealing that many deleterious mutations affect function outside the active site through allosteric coupling.
bioRxiv · Apr 13, 2022Biophysics