J. M. Flynn

This study identifies hyperactive mutations in SARS-CoV-2 Mpro that increase enzyme activity and contribute to drug resistance, finding them more prevalent than binding-reducing mutations.

The paper systematically identifies new allosteric regulatory sites in Gsp1/Ran by mutational scanning, revealing that many deleterious mutations affect function outside the active site through allosteric coupling.

The paper assembles genomes and identifies structural variants in two Lake Whitefish species pairs using long and short reads, finding that SVs cover more genome than SNPs and are linked to transposable elements.

This paper describes three recent sex chromosome-to-autosome fusions in a Drosophila virilis strain, linking satellite DNA abundance to increased genome instability and karyotype variability.

The paper estimates copy number change rates in tandem repeats across mouse lines over generations, finding stability in CAG repeats and variation in other repeats.

This study maps the fitness effects of Hsp90 variants across multiple environments, showing widespread environmental dependence and selection for robustness.

The paper measures the fitness effects of historical amino acid substitutions in Hsp90 across evolutionary timescales, finding pervasive epistasis influencing sequence evolution and entrenchment.

This study quantifies mutation rates and selective pressures on satellite DNA in Daphnia pulex, showing high mutation rates and evidence of purifying selection in non-MA population isolates.

The paper models how resource availability affects encounter rates among jackals and investigates how disease outbreaks in zebras can indirectly induce disease in jackals.

This study identifies genes in Pseudomonas aeruginosa essential for mucin utilization, highlighting the glyoxylate pathway and proteases like LasB and AprA.