A Multi-Phenotype System to Discover Therapies for Age-Related Dysregulation of the Immune Response to Viral Infections
B. W. White, B. Komalo, L. Nicolaisen, M. Donne, C. Marsh, R. M. DeVay, A. M. Nguyen, W. Cousin, J. Heinrich, W. J. Van Trump, T. Plott, C. J. Fuller, D. Nguyen, D. Chen, D. Bucher, , B. Kamens
This paper develops a multi-phenotype system to identify compounds that rejuvenate the immune response in older adults to viral infections, finding disulfiram and triptonide as promising candidates.
bioRxiv · Jul 30, 2020 · PreprintImmunology