D. Nguyen

Manipulating the EphB4-ephrinB2 axis to reduce metastasis in HSNCC

This study shows that targeting the EphB4-ephrinB2 axis with engineered ligands reduces metastasis in HNSCC by modulating tumor microenvironment and immune responses.

Floral phenotypic divergence and genomic insights in an Ophrys orchid: Unraveling early speciation processes

The paper investigates early speciation processes in Ophrys orchids by analyzing phenotypic and genomic divergence in six populations, identifying a genomic island linked to floral odor variation and candidate genes involved in color and odor pathways.

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

This study develops rod-shaped Janus base nanopieces for improved tissue penetration and therapeutics delivery, showing better efficacy than spherical lipid nanoparticles in ovarian cancer models.

3D-Printable Non-invasive Head Immobilization System for Non-Human Primates

This paper introduces a 3D-printable non-invasive head immobilization system for macaques, showing comparable gaze precision and accuracy to traditional headposts.

Project ChemicalBlooms: Collaborating with Citizen Scientists to Survey the Chemical Diversity and Phylogenetic Distribution of Plant Epicuticular Wax Blooms

The paper surveys plant epicuticular wax blooms using citizen scientists, finding lineage-specific chemical patterns and suggesting non-biosynthetic mechanisms for triterpenoid-rich blooms.

Intracellular Pseudomonas aeruginosa within the airway epithelium of Cystic Fibrosis lung tissues

The paper detects intracellular Pseudomonas aeruginosa in CF lung tissues using microscopy and culture, showing its presence in 3 out of 7 analyzed lungs.

Assessing the global prevalence of wild birds in trade

This paper quantifies global bird trade prevalence using seven datasets, identifying species at risk and informing conservation strategies.

The carboxyl-terminal sequence of PUMA binds to both anti-apoptotic proteins and membranes.

This study identifies a novel binding site in PUMA's carboxyl-terminal sequence that contributes to its resistance to BH3-mimetic displacement from anti-apoptotic proteins.

Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC

The paper describes piperidine-based CD4-mimetic compounds that expose HIV-1 Env epitopes, increasing sensitivity to ADCC by targeting Asp368.

Integrating inflammatory biomarker analysis and artificial intelligence-enabled image-based profiling to identify drug targets for intestinal fibrosis

The paper identifies potential drug targets for intestinal fibrosis by combining image-based morphology analysis with AI and inflammatory biomarker measurements.

The ER protein translocation channel subunit Sbh1 controls virulence of Cryptococcus neoformans

This paper shows that Sbh1 in Cryptococcus neoformans regulates virulence by controlling the secretion of virulence factors through the secretory pathway.

ER translocation of suboptimal targeting sequences depends on Sec61β/Sbh1 and its phosphorylation

The paper shows that phosphorylation of Sbh1 regulates ER translocation of proteins with suboptimal targeting sequences by inducing conformational changes.

Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting

The paper identifies substrates and a novel component, hSnd3, in the hSnd2-dependent ER protein targeting pathway through proteomic analysis.

WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation

This study identifies WDR5 as an epigenetic regulator that promotes breast cancer growth and metastasis through KMT2-independent translation regulation, suggesting therapeutic strategies targeting WDR5.

Seasonal dynamics of the wild rodent faecal virome

This study examines seasonal changes in the virome of wild rodents, finding that many viruses are seasonally transient and linked to host and environmental factors.

HA and M2 sequences alter the replication of 2013-16 H1 Live Attenuated Influenza Vaccine Infection in Human Nasal Epithelial Cell cultures

The paper compares replication of H1 LAIVs with different HA and M2 sequences in human nasal epithelial cells, finding HA differences impact replication and immune response.

Across functional boundaries: making non-neutralizing antibodies to neutralize HIV-1 and mediate Fc-mediated effector killing of infected cells

This paper designs Ab-CD4 chimeric proteins that open HIV-1 Env trimers to expose non-neutralizing epitopes, enabling both neutralization and ADCC against HIV-1.

Maturation of Human Long-lived Plasma Cells Results in Resistance to Apoptosis by Transcriptional and Epigenetic Regulation

This study shows human blood ASCs undergo transcriptional and epigenetic changes in the BM microniche to become apoptotic-resistant LLPC.

Xenogeneic Skin Transplantation Promotes Angiogenesis and Tissue Regeneration Through Vitamin D-Activated Trem2+ Macrophages

The paper shows that vitamin D-activated Trem2+ macrophages promote angiogenesis and reduce fibrosis, offering a new strategy for advanced cell therapies in complex wounds.

A covalently crosslinked bioink for multi-materials drop-on-demand 3D bioprinting of three-dimensional cell cultures

This paper develops a covalently crosslinked bioink and a drop-on-demand 3D bioprinting platform to rapidly create complex 3D cell cultures with multiple hydrogel environments.

The Need for Sustainable Leadership in Academia - a German Case Study

This study surveys German academics to show that most leaders lack preparation and desire leadership training to improve the academic system.

The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28

This paper shows that CD28-TMD in CARs forms heterodimers with endogenous CD28, affecting T-cell responses and surface expression.

A Multi-Phenotype System to Discover Therapies for Age-Related Dysregulation of the Immune Response to Viral Infections

This paper develops a multi-phenotype system to identify compounds that rejuvenate the immune response in older adults to viral infections, finding disulfiram and triptonide as promising candidates.

Identification and Characterization of a B-Raf Kinase Alpha Helix Critical for the Activity of MEK Kinase in MAPK Signaling

The paper identifies an alpha helix on B-Raf critical for its interaction with MEK and oncogenic activity, suggesting it as a potential drug target for melanoma treatment.

Novel PE and APC Tandems: Additional Near-Infrared Fluorochromes for Use in Spectral Flow Cytometry

The paper introduces six new near-infrared fluorochromes for spectral flow cytometry, enhancing the number of available fluorochromes for 3-laser systems.

Evaluation of Different PCR Assay Formats for Sensitive and Specific Detection of SARS-CoV-2 RNA

The paper evaluates different PCR formats for SARS-CoV-2 RNA detection, finding that nested PCR with agarose gel electrophoresis is sensitive and specific but has variable sensitivity depending on transcript length.

Mechano-bactericidal nanopillars require external forces to effectively kill bacteria

This study shows that nanopillar surfaces require external forces to kill bacteria, challenging the idea that nanopillars alone are effective antibacterial agents.

Association of zinc-finger antiviral protein (ZAP) binding to viral genomic RNA with attenuation of replication of echovirus 7

This study investigates how ZAP binding to viral RNA affects echovirus 7 replication, showing specific dinucleotide recognition and interactions with OAS3 and stress granules.

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

Deep Learning Identifies Cardiomyocyte Nuclei in Murine Tissue with High Precision

The paper develops a deep learning model to identify cardiomyocyte nuclei in mouse heart tissue using image segmentation and immunostaining, achieving high sensitivity and specificity.