D. Bucher

Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 reveal a novel binding site for positive modulators

The paper determines high-resolution Cryo-EM structures of the human Kv3.1 channel, both apo and ligand-bound, revealing a novel binding site for positive modulators.

Clathrin-independent endocytosis of Human Papillomaviruses is facilitated by actin nucleation promoting factor WASH

This study identifies WASH as a facilitator of clathrin-independent endocytosis of HPV16, independent of retromer and SNX-BAR.

Insight into Lipopolysaccharide Translocation by Cryo-EM structures of a LptDE Transporter in Complex with Pro-Macrobodies

The paper uses cryo-EM to determine structures of the LptDE transporter complex with Pro-Macrobodies, revealing partially and fully opened states of the transporter during LPS translocation.

Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation

This paper reports the cryo-EM structure of hTRPV4 in an open conformation induced by 4-PDD agonist, revealing molecular mechanisms of activation and providing a template for inhibitor design.

A Multi-Phenotype System to Discover Therapies for Age-Related Dysregulation of the Immune Response to Viral Infections

This paper develops a multi-phenotype system to identify compounds that rejuvenate the immune response in older adults to viral infections, finding disulfiram and triptonide as promising candidates.

Focal adhesion-generated cues in extracellular matrix regulate cell migration by local induction of clathrin-coated plaques

This study identifies Eps15 and Eps15R as key regulators of clathrin-coated plaque formation, linking ECM remodeling by focal adhesions to cell migration directionality.