Exploratory re-encoding of Yellow Fever Virus genome: new insights for the design of live-attenuated viruses
R. Klitting, T. Riziki, G. Moureau, G. Piorkowski, E. A. Gould, X. de Lamballerie
This study re-encodes the Yellow Fever Virus genome with synonymous mutations to create attenuated strains, finding that certain mutations reduce virulence without significantly affecting replication fitness.
bioRxiv · May 30, 2018Microbiology