CaMKII binds both substrates and activators at the active site
C. Ozden, R. Sloutsky, T. Mitsugi, N. Santos, E. Agnello, C. Gaubitz, J. Foster, E. Lapinskas, E. A. Esposito, T. Saneyoshi, B. A. Kelch, S. C. Garman, Y. Hayashi, M. Stratton
This study challenges a longstanding model of CaMKII activation by showing that activators and substrates bind to a single site rather than distinct S- and T-sites.
bioRxiv · Oct 25, 2020Biochemistry