Author

M. Stratton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1 Microbiology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:statistical model· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. C. Garman· 2 shared A. B. Brinkman· 1 shared A. Butler· 1 shared A. Canella· 1 shared A. Ferrari· 1 shared A. Francois· 1 shared A. L. Richardson· 1 shared A. P. Torres-Ocampo· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

S. C. Garman

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Author profile →

7 papers

Recent·Most cited

Structural and functional analysis of the Nipah virus polymerase complex

S. Hu, H. Kim, P. Yang, Z. Yu, B. Ludeke, S. Mobilia, J. Pan, M. Stratton, Y. Bian, R. Fearns, J. Abraham

This study determines the cryo-EM structure of the Nipah virus polymerase complex and identifies key domains critical for replication and transcription.

bioRxiv · May 29, 2024Microbiology

A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation

V. C. B. Nguyen, C. Özden, K. Dong, O. Koc, A. P. Torres-Ocampo, N. Dziedzic, D. Flaherty, J. Huang, S. Sankura, N. L. Abromson, D. R. Tomchick, R. A. Fissore, J. Chen, S. C. Garman, M. Stratton

This study identifies a domain-swapped conformation in CaMKII that enables linker-mediated allosteric regulation, demonstrated through structural, computational, and live-cell analyses.

bioRxiv · Mar 24, 2024Biochemistry

Post-mitotic centriole disengagement and maturation leads to centrosome amplification in polyploid trophoblast giant cells

G. Buss, M. Stratton, L. Milenkovic, T. Stearns

The paper examines centriole and centrosome dynamics in trophoblast giant cells during endocycles, finding that centrioles disengage and convert to centrosomes, increasing their number but not as much as DNA replication.

bioRxiv · May 25, 2022Cell Biology

Long-term ketogenic diet increases expression of SOX2-dependent oligodendrocyte- and myelination-associated genes in the aged mouse brain.

M. Stratton, J. A. Lopez-Dominguez, A. Canella, J. J. Ramsey, G. A. Cortopassi

This study finds that a long-term ketogenic diet increases SOX2-dependent oligodendrocyte and myelination gene expression in aged mouse brains.

bioRxiv · Feb 22, 2022 · PreprintPhysiology

Molecular signature of RV cardiac remodeling associated with Polymerase Gamma mutation

M. W. Gorr, A. Francois, L. M. Marcho, T. Saldana, E. McGrail, N. Sun, M. Stratton

This study characterizes cardiac remodeling in POLG mutant mice, identifying sex-specific differences and RNA-seq-driven insights into inflammation, fibrosis, and heart failure pathways.

bioRxiv · Feb 11, 2022Pathology

CaMKII binds both substrates and activators at the active site

C. Ozden, R. Sloutsky, T. Mitsugi, N. Santos, E. Agnello, C. Gaubitz, J. Foster, E. Lapinskas, E. A. Esposito, T. Saneyoshi, B. A. Kelch, S. C. Garman, Y. Hayashi, M. Stratton

This study challenges a longstanding model of CaMKII activation by showing that activators and substrates bind to a single site rather than distinct S- and T-sites.

bioRxiv · Oct 25, 2020Biochemistry

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

A. B. Brinkman, S. Nik-Zainal, F. Simmer, F. G. Rodriguez-Gonzalez, M. Smid, L. B. Alexandrov, A. Butler, S. Martin, H. Davies, G. Dominik, X. Zou, M. Ramakrishna, J. Staaf, M. Ringner, A. Sieuwerts, , H. G. Stunnenberg

The paper shows PMDs are hypervariable in breast cancer and drive CGI hypermethylation, but do not significantly repress cancer genes.

bioRxiv · Nov 15, 2018Cancer Biology