Immune landscape of a genetically-engineered murine model of glioma relative to human glioma by single-cell sequencing
D. B. Zamler, T. Shingu, L. M. Kahn, C. Kassab, M. Ott, K. Tomczak, J. Liu, Y. Li, I. P. Lai, C. Yee, K. Rai, A. B. Heimberger, G. Draetta, J. Hu
This study compares the immune landscape of a genetically-engineered murine glioma model to human glioma using single-cell sequencing, finding similar immunosuppressive features but differences in immune cell composition between mouse models and human samples.
bioRxiv · May 11, 2020 · PreprintCancer Biology