Coordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC
T. Snelling, N. Shpiro, R. Gourlay, F. Lamoliatte, P. Cohen
This study identifies how ADP-heptose activates ALPK1 and downstream inflammatory pathways through coordinated action of TRAF6, TRAF2/c-IAP1, and LUBAC.
bioRxiv · Jul 19, 2022Immunology