P. Cohen

Genomic architecture of nestmate recognition cues in the desert ant

The paper performs two GWAS analyses on CHCs in desert ants to identify genetic loci associated with nestmate recognition cues, finding 99 candidate QTLs and supporting the Gestalt colony odor model.

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.

This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.

Ester-linked ubiquitin sites formed by HOIL-1 in TLR7 signaling include four novel ubiquitin dimers

The paper identifies novel ester-linked ubiquitin dimers formed by HOIL-1 in TLR7 signaling, expanding the types of ubiquitin dimers in cells.

Control of lipolysis by a population of oxytocinergic sympathetic neurons

This study identifies a population of oxytocinergic sympathetic neurons that regulate adipose tissue lipolysis and metabolic homeostasis in mice and humans.

Coordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC

This study identifies how ADP-heptose activates ALPK1 and downstream inflammatory pathways through coordinated action of TRAF6, TRAF2/c-IAP1, and LUBAC.

Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single cell RNA sequencing

This study evaluates scRNA-Seq methods for detecting SARS-CoV-2 subgenomic mRNAs, finding that 10X 5' with extended R1 sequencing best captures these viral RNAs at single-cell resolution.

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice

This study compares Exo1DA/DA mice with nuclease-dead EXO1 to Exo1-/- and Exo1+/+ mice to show EXO1 has both enzymatic and scaffolding roles in DNA repair, immune response, and tumor suppression.

HOIL-1-catalysed ubiquitylation of unbranched glucosaccharides and its activation by ubiquitin oligomers

This study shows HOIL-1 ubiquitylates unbranched glucosaccharides and its activity is enhanced by ubiquitin oligomers, preventing toxic polysaccharide accumulation.

Salt-inducible kinase (SIK) inhibition is protective in a mouse model of asthma

This study shows that inhibiting SIKs reduces IL-13 secretion from ILC2s and alleviates allergic asthma symptoms in mice.

Blunting of insulin-stimulated glucose uptake in brown adipose tissue induces systemic metabolic dysregulation in female mice

This study shows that reducing glucose uptake in brown adipose tissue in female mice leads to systemic metabolic issues, independent of thermogenesis.

Single Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis

This study shows that adipocyte signals can drive iWAT browning through macrophage-like cells, independent of sympathetic nerves.

AGO HITS-CLIP in Adipose Tissue Reveals miR-29 as a Post-Transcriptional Regulator of Leptin

The paper uses HITS-CLIP to identify miR-29 as a key post-transcriptional regulator of leptin in adipose tissue, with implications for obesity treatment.

Brown Adipose Tissue is Associated with Improved Cardiometabolic Health and Regulates Blood Pressure

This study links brown adipose tissue (BAT) to improved cardiometabolic health and blood pressure regulation in humans.

MOTS-c is an Exercise-Induced Mitochondrial-Encoded Regulator of Age-Dependent Physical Decline and Muscle Homeostasis

This study shows that MOTS-c, a mitochondrial-encoded peptide, improves physical performance and muscle homeostasis across ages in mice and humans, suggesting mitochondrial genes regulate aging.

Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses

The paper identifies salt-inducible kinases (SIKs) as regulators of TGFβ-mediated transcriptional and apoptotic responses through pharmacological and genetic approaches.

Incipient species or social polymorphism? Diversity in the desert ant Cataglyphis

The paper investigates whether distinct mitochondrial DNA lineages in desert ants are incipient species or social polymorphism within a single species.

Vasculature-associated adipose tissue macrophages dynamically adapt to inflammatory and metabolic challenges

The paper identifies vasculature-associated adipose tissue macrophages (VAMs) and shows how they adapt to metabolic and inflammatory challenges in epididymal white adipose tissue.