FOXM1 Modulation Alleviates Epithelial Remodeling and Inflammation in Eosinophilic Esophagitis
Masaru Sasaki, Joshua X. Wang, Yusen Zhou, Kanak V. Kennedy, Ryugo Teranishi, Takefumi Itami, Satoshi Ishikawa, Takeo Hara, Heidi Winters, Emily A. McMillan, Mark Mahon, Hailey Golden, Diya Dhakal, Alyssa Baccarella, Chizoba N. Umeweni, , Amanda B. Muir
This study identifies FOXM1 as a key driver of epithelial disruption in EoE, showing that its inhibition restores differentiation, reduces hyperplasia, and improves barrier function.
bioRxiv · May 25, 2025 · PreprintMolecular Biology