Amanda B. Muir

The paper uses scRNA-seq to compare IL-13-treated esophageal organoids with EoE biopsies, revealing shared cell state heterogeneity and differentiation hierarchy dysregulation.

This study shows that NIX-mediated mitochondrial remodeling is essential for esophageal epithelial differentiation and that its disruption may contribute to eosinophilic esophagitis.

This study shows that Prostaglandin E2 reverses myofibroblast differentiation in EoE via the cAMP/YAP/THBS-1 pathway, suggesting it as a potential treatment for fibrostenotic EoE.

This study investigates profibrotic changes in a fetal lamb model of long gap esophageal atresia following tension application, showing increased collagen deposition and TGFB signaling.

SUMMIT traces mitochondrial mutations in human tissues to identify spatially localized clones and their transcriptomic profiles.

This study identifies FOXM1 as a key driver of epithelial disruption in EoE, showing that its inhibition restores differentiation, reduces hyperplasia, and improves barrier function.

This study identifies IL-13 as a driver of increased mitochondrial mass in esophageal keratinocytes, impairing squamous cell differentiation and contributing to eosinophilic esophagitis.

This study investigates interferon-γ signaling in eosinophilic esophagitis, showing its impact on epithelial barrier function and apoptosis in esophageal epithelial cells.

This study optimizes ADF-based medium for normal human esophageal organoids and models pathological changes using inflammatory and pharmacological stimuli.

The paper investigates autophagy's role in esophageal homeostasis, finding that high autophagic vesicle content in basal cells correlates with limited proliferation and enhanced self-renewal.

The paper identifies clonal cell states in Barrett's esophagus and links them to esophageal adenocarcinoma progression through single-cell lineage tracing and transcriptional profiling.

This study uses single-cell RNA sequencing to identify cellular diversity and age-related mitochondrial dysfunction in murine esophageal epithelium.