An autoimmunity-associated allele of PTPN22 enhances the innate immune response to promote protection against acute coronavirus infection
Alec M Bevis, Kathryn J.L.H. Rosa, Nancy Schwarting, Tammy Cockerham, Catherine M. Kerr, Sunil More, Anthony R. Fehr, Robin C. Orozco
This study shows that the PTPN22 1858C>T allele enhances innate immunity and protects against acute coronavirus infection by improving NK cell function.
Proceedings of the National Academy of Sciences · Mar 18, 2026Peer-reviewedImmunology