Anthony R. Fehr

This study compares how SARS-CoV-2 and MERS-CoV nsp1 proteins affect host protein synthesis and the integrated stress response, revealing differential impacts on eIF2 phosphorylation and stress granule formation.

This study shows that the PTPN22 1858C>T allele enhances innate immunity and protects against acute coronavirus infection by improving NK cell function.

This paper shows PARP14 promotes IFN production and has both antiviral and proviral functions against multiple viruses.

This paper investigates how mutations in the coronavirus Mac1 protein affect ADP-ribose binding and hydrolysis, revealing distinct roles in viral replication stages.

This study shows that IFN-γ is required for efficient replication of JHMV in mouse brains, despite reduced viral replication in IFN-γ and IFN-γR knockout mice.

This study identifies pyrrolo-pyrimidine-based Mac1 inhibitors that inhibit MHV and SARS-CoV-2 replication, with some compounds showing IFN-dependent antiviral activity.

This study investigates how the nitrogen phosphotransferase system (PTSNtr) in Pseudomonas aeruginosa regulates quorum sensing, showing that PtsO and PtsN have distinct roles and regulons in controlling virulence gene expression.

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.

This paper identifies small molecule inhibitors of SARS-CoV-2 Mac1 that inhibit coronavirus replication, validating Mac1 as an anti-viral target.

This study shows that SARS-CoV-2 nsp15 inhibits dsRNA-induced antiviral signaling, which is necessary for viral replication in nasal epithelial cultures.