Atom-economic enantioselective photoenzymatic radical hydroalkylation via single-electron oxidation of carbanions
Jin Zhu, Qiaoyu Zhang, Tao Gu, Binbin Chen, Mingzhe Ma, Xiaoyu Wang, Xiao Liu, Mingjie Ma, Binju Wang, Yajie Wang
This paper introduces a photoenzymatic system for enantioselective hydroalkylation of C(sp3)-H bonds using a flavin-dependent ene-reductase and fluorescein, achieving atom-economic and enantiodivergent reactions.
bioRxiv · Dec 8, 2024Biochemistry