Jun Li

Stromal control of sympathetic rewiring in metastatic lymph nodes

This study shows that tumor-driven remodeling of metastatic lymph nodes involves sympathetic neural rewiring mediated by stromal HGF and mechanical cues.

Targeting homologous recombination repair to potentiate fluoroquinolone efficacy in Mycobacterium abscessus

This study identifies homologous recombination as a key mechanism of fluoroquinolone resistance in Mycobacterium abscessus and shows that targeting HR enhances FQ efficacy in vitro and in vivo.

Progressive plyometric training improves jumping performance and reduces force-velocity imbalance in collegiate volleyball players

A 32-week plyometric training program improved jumping performance and reduced force-velocity imbalance in collegiate volleyball players compared to a low-intensity control group.

Parallel Activation and Interference CRISPR (PAIR) with Sequencing Uncovers DNA Repair Networks Guiding Precision Cell Engineering

PAIR combines CRISPR activation and RNA knockdown to study bidirectional gene interactions in DNA repair, revealing strategies to enhance CRISPR-based gene editing precision.

NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages drive chemoradiotherapy resistance in esophageal squamous cell carcinoma

This study identifies NRF2 pathway activation and SPP1⁺TREM2⁺ macrophages as drivers of chemoradiotherapy resistance in ESCC through multi-omics analysis of clinical trial data.

MemConverter: An Iterative Pipeline for Reprogramming Protein Localization in Membrane or Aqueous Solution

MemConverter reprograms protein localization between membrane and aqueous environments using MCP-guided sequence design and AlphaFold2 refinement, achieving stable integration or solubility.

Evidence of an Allostatic Response by Intestinal Tissues Following Induction of Joint Inflammation

The paper investigates how intestinal tissues respond to joint inflammation in a rat model, finding region-specific transcriptomic and microbiome changes.

Telomere-to-telomere gap-free and phased genome assembly reveals post-allopolyploidization subgenomic diversification of tobacco centromeres

This study presents a gap-free, phased genome assembly of tobacco, revealing subgenomic diversification of centromeres after allopolyploidization.

Evolution of the Spatial transcriptomic landscape during the progression of high-grade pancreatic intraductal papillary mucinous neoplasms to invasive cancer

This study uses spatial transcriptomics to analyze the progression of high-grade IPMN to invasive PDAC, identifying clonal evolution, key drivers, immune shifts, and CAF roles.

Plasmid dependent phage eliminate pathogenic bacteria and antibiotic resistance plasmids from the chicken gut microbiome

This study shows that plasmid-dependent phage treatment removes pathogenic bacteria and antibiotic resistance plasmids from chicken gut microbiomes without disrupting overall microbiome composition.

A standardized, open-source, portable model for noninvasive joint injury in mice

The paper introduces a standardized, open-source protocol for noninvasive joint injury in mice, resulting in post-traumatic osteoarthritis, and provides tools for reproducibility and analysis.

Drosophila host defense mechanisms against filamentous fungal pathogens with diverse lifestyles

This study investigates Drosophila immune responses to diverse fungal pathogens, identifying the Toll pathway and melanization as key defenses, while highlighting fungal adaptations to evade these mechanisms.

PTX3 Governs Fibroblast-Epithelial Dynamics in Lung Injury and Repair

This study identifies PTX3 as a key antifibrotic factor secreted by fibroblasts that modulates epithelial repair in acute injury and exacerbates damage in chronic injury.

OriGene: A Self-Evolving Virtual Disease Biologist Automating Therapeutic Target Discovery

OriGene identifies therapeutic targets by integrating diverse data modalities and outperforms human experts and models in accuracy and robustness.

Aptamer-Enabled Discovery and Clinical Analysis of Exosomal Surface Biomarkers in Hepatocellular Carcinoma

The paper develops an aptamer-based platform for discovering and analyzing exosomal surface biomarkers in hepatocellular carcinoma, achieving high accuracy in clinical validation.

Physiological Assembly Of Functionally Active 30S Ribosomal Subunits From In Vitro Synthesized Parts

The paper constructs functional synthetic 30S ribosomal subunits in vitro and reports their efficiency and component requirements.