Granulocyte colony-stimulating factor acts through calcium-permeable AMPA receptors to potentiate cocaine reward
Rebecca S. Hofford, Rashaun S. Wilson, Colin J. McArdle, Tanner J. Euston, Jonathon P. Sens, Abigail Mastrantoni, Taylor McCabe, Katherine R. Meckel, Weiwei Wang, Kelsey E. Lucerne, Aya Osman, Kimberly F. Raab‐Graham, TuKiet T. Lam, Drew D. Kiraly
This study shows that G-CSF enhances cocaine reward by promoting glutamatergic synaptic remodeling in the nucleus accumbens through calcium-permeable AMPA receptors.
bioRxiv · Feb 2, 2026 · PreprintNeuroscience