mPFC Synaptosome Proteomics Reveals Novel Pathways and Muscarinic Receptor Changes in a Learned Helplessness Mouse Model
Zuhair I. Abdulla, Rolando Garcia-Milian, Ernestine Giahyue, Sofia Fertuzinhos, Florine Collin, Weiwei Wang, TuKiet T. Lam, Angus Clark Nairn, Marina R. Picciotto
The paper identifies proteomic changes in mPFC synaptosomes of mice exposed to inescapable stress, highlighting muscarinic receptor alterations and signaling pathway disruptions linked to depression.
eNeuro · Apr 1, 2026Peer-reviewedNeuroscience