Tiffany Chen

Common viral infections seed regionally distinct resident memory T cells in the human CNS

The paper identifies regionally distinct CD8+ resident memory T cells in the human CNS shaped by viral infections using single-cell RNA sequencing and T cell receptor analysis.

Circulating and brain-resident memory CD8+ T cells seed distinct bystander TRM-like populations in glioblastoma

This study identifies that circulating and brain-resident memory CD8+ T cells contribute to distinct bystander TRM-like populations in glioblastoma, with brain TRM being a major source in GBM.

Cerebellar acceleration of learning in an evidence-accumulation task

The paper shows that cerebellar perturbations in mice lead to faster learning in a sensory evidence-accumulation task, linked to enhanced focus on current trials and altered neocortical activity.

LabOS: The AI-XR Co-Scientist That Sees and Works With Humans

LabOS is an AI co-scientist that integrates computational reasoning with physical experimentation through multimodal perception and human-AI collaboration, enhancing scientific discovery in biomedical and materials science.

Bidirectional regulation of glycoprotein nonmetastatic melanoma protein B by β-glucocerebrosidase deficiency in GBA1 isogenic dopaminergic neurons from a patient with Gaucher disease and parkinsonism

The paper investigates how GBA1 mutations affect glycoprotein nonmetastatic melanoma protein B (GPNMB) expression in dopaminergic neurons, linking lipid accumulation to Parkinson's disease risk.

Alarm functions of PD-1+ brain resident memory T cells

This study shows brain-resident memory T cells (TRM) can rapidly remodel the CNS immune landscape through activation of multiple immune cells, and PD-1 inhibits granzyme B but not alarm responses.