Sex-Dependent Epigenomic and Transcriptomic Reprogramming Links Maternal Obesity to Cardiac Remodeling in Adult Offspring
Tim D. Wilson, Elysse A. Phillips, Yem J. Alharithi, Cameron Broberg, Joshua Vanderpool, Shauna K. Rakshe, Suzanne S. Fei, Brett A. Davis, Sheryl E. Koch, Zhehao Zhu, Lyndsey E. Shorey‐Kendrick, Sushil Kumar, Lucia Carbone, Yabing Chen, Jamie Oi-Ting Lo, , Alina Maloyan
This study shows maternal obesity causes sex-dependent epigenetic and transcriptomic changes in offspring hearts, leading to sex-specific cardiac remodeling and disease risk.
American Journal of Physiology-Heart and Circulatory Physiology · Sep 8, 2026Peer-reviewedMolecular Biology