Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in H3K27M-mutant gliomas
Georgios Batsios, Céline Taglang, Suresh Udutha, Anne Marie Gillespie, Simon P. Robinson, Timothy Phoenix, Sabine Mueller, Sriram Venneti, Carl Koschmann, Pavithra Viswanath
This paper shows lactate supports nucleotide biosynthesis in H3K27M-mutant gliomas and enables deuterium metabolic imaging of tumor proliferation.
Science Translational Medicine · Feb 11, 2026Peer-reviewedCancer Biology