Pavithra Viswanath

This paper shows that combining GLP1R agonists with vorasidenib induces synergistic cytotoxicity in mIDH glioma by generating peroxynitrite through mitochondrial redox metabolism.

This study creates a mouse model of IDH-mutant 1p/19q-codeleted oligodendroglioma and identifies genotype-specific phenotypes and molecular features.

This study identifies ENO2 and PHGDH as metabolic vulnerabilities in 1p/19q co-deleted oligodendrogliomas and shows that their inhibition, combined with deuterium metabolic imaging, provides a therapeutic and imaging strategy.

This paper shows lactate supports nucleotide biosynthesis in H3K27M-mutant gliomas and enables deuterium metabolic imaging of tumor proliferation.

This study identifies PHGDH-driven D-2HG production as a mechanism of resistance to vorasidenib in IDHm gliomas and introduces deuterium metabolic imaging as a non-invasive method to detect resistance.

This study identifies metabolic vulnerabilities in glioblastomas driven by TERT and shows that combining GCLC and glutamine-utilizing enzyme inhibitors synergistically targets these vulnerabilities.

This study shows imipridones induce GABA accumulation in diffuse midline gliomas, which can be used for non-invasive imaging and therapy.