Céline Taglang

This paper shows that combining GLP1R agonists with vorasidenib induces synergistic cytotoxicity in mIDH glioma by generating peroxynitrite through mitochondrial redox metabolism.

This study identifies ENO2 and PHGDH as metabolic vulnerabilities in 1p/19q co-deleted oligodendrogliomas and shows that their inhibition, combined with deuterium metabolic imaging, provides a therapeutic and imaging strategy.

This paper shows lactate supports nucleotide biosynthesis in H3K27M-mutant gliomas and enables deuterium metabolic imaging of tumor proliferation.

This study identifies PHGDH-driven D-2HG production as a mechanism of resistance to vorasidenib in IDHm gliomas and introduces deuterium metabolic imaging as a non-invasive method to detect resistance.

This study identifies metabolic vulnerabilities in glioblastomas driven by TERT and shows that combining GCLC and glutamine-utilizing enzyme inhibitors synergistically targets these vulnerabilities.

This study shows imipridones induce GABA accumulation in diffuse midline gliomas, which can be used for non-invasive imaging and therapy.