Ting Li

Lysosomal Aspartylglucosaminidase Couples Glycoprotein Catabolism to Cell-Surface GlycoRNA Production

The paper identifies lysosomal aspartylglucosaminidase (AGA) as a rate-limiting regulator linking glycoprotein catabolism to glycoRNA formation.

Cardiac oxidative stress monitoring enabled by hierarchical mechanical adaptation

This paper introduces E-cardiac, a biosensor that monitors oxidative stress in beating hearts with mechanical adaptation, distinguishing ischemia-reperfusion injury severity and detecting the ECG blind window.

Curvature-mediated prewetting organize mitochondrial nucleoid

This study shows membrane curvature drives prewetting transitions that organize mitochondrial nucleoids through localized protein condensation.

Mapping rare protein-coding variants on multi-organ imaging traits

The paper identifies rare protein-coding variants associated with multi-organ MRI traits using exome-wide association analysis in the UK Biobank.

De novo generation of antibody CDRH3 with a pre-trained generative large language model

This paper introduces PALM, a pre-trained generative large language model for de novo antibody CDRH3 design, and A2binder for predicting antigen-antibody binding, showing effectiveness against SARS-CoV-2 variants.

Insights into mortality patterns and causes of death through a process point of view

The paper models mortality patterns using a process point of view framework, linking biological mechanisms to death as challenges to vitality, and applies it to Swedish mortality data to explain epidemiological transitions.

Genome sequencing of the perciform fish Larimichthys crocea provides insights into stress adaptation

This study sequenced the genome of the large yellow croaker to understand its adaptation to environmental stress, finding expanded gene families and novel regulatory networks involved in stress response.