Jie Chen

A Conserved SIFamide Circuit Functions as the Insect Vagus Nerve

The paper identifies the SIFamide circuit in Drosophila as the functional homolog of the mammalian vagus nerve, showing its role in integrating metabolic and reproductive signals.

A pesticide hijacks a neurohormonal circuit to block ovulation in insects

This study shows that emamectin benzoate suppresses ovulation in insects by targeting octopaminergic neurons and disrupting reproductive processes.

Identification of highly immunogenic endogenous dsRNAs from cellular MDA5 filaments

The paper identifies immunogenic endogenous dsRNAs by isolating MDA5 filaments and shows their suppression by ADAR1 and DDX3X.

rDNA breaks activate dsRNA pattern recognition through sense-antisense transcription

The paper shows that rDNA breaks generate sense-antisense rRNA transcripts that activate immune signaling via MDA5 and RIG-I.

Reverse-engineering amyloid strains with generative protein design

This study uses generative protein design to explore how sequences encode amyloid fibril structures, showing a continuous compatibility between sequences and a common amyloid fold.

Transition metal-triggered immunity via an Arabidopsis NLR pair

The paper shows that two Arabidopsis NLRs, STM1 and STM2, antagonistically regulate transition metal-triggered immunity, balancing pathogen resistance and metal toxicity.

The 5-HT1A receptor antagonist WAY-100635 maleate reprograms metabolism to promote RGC differentiation and regeneration in retino-visual centers

This study identifies WAY-100635 as a neuroprotectant that reprograms metabolism to promote RGC differentiation and regeneration in glaucoma models.

The anti-retroviral therapy emtricitabine affects skeletal muscle DNA methylation and transcriptome patterns in a male HIV mouse model

This study examines how emtricitabine, an antiretroviral drug, alters DNA methylation and transcriptome patterns in skeletal muscle of HIV-infected mice, revealing potential mechanisms of ART-related muscle dysfunction.

Loss of virulence of Botrytis cinerea mutants defective in phytotoxin production is restored by modifying inoculation medium

The paper shows that Botrytis cinerea mutants lacking phytotoxins regain virulence when inoculated with yeast extract, highlighting the importance of phytotoxins and inoculation conditions in virulence.

Mapping rare protein-coding variants on multi-organ imaging traits

The paper identifies rare protein-coding variants associated with multi-organ MRI traits using exome-wide association analysis in the UK Biobank.

Comprehensive Infectome Analysis Reveals Diverse Infectious Agents with Zoonotic Potential in Wildlife

The paper analyzes wildlife infectomes to identify zoonotic pathogens, finding 62 novel pathogens including a new coronavirus genus and highlighting high pathogen diversity in Carnivora and Rodentia.

The pivotal role of the X-chromosome in the genetic architecture of the human brain

The paper investigates the genetic impact of the X-chromosome and sex differences in the human brain, identifying 72 genome-wide significant trait-locus pairs linked to brain-related disorders.

Genetic influences on the shape of brain ventricular and subcortical structures

The paper identifies 60 genetic loci associated with brain ventricular and subcortical shape features using shape measures from over 45,000 UK Biobank and ABCD study subjects.

Heart-brain connections: phenotypic and genetic insights from 40,000 cardiac and brain magnetic resonance images

The paper investigates phenotypic and genetic links between heart and brain using MRI data from 40,000 UK Biobank subjects, finding strong correlations and shared genetic influences.