Inhibition of Posterior Thalamic Nuclei Attenuates CGRP-induced Migraine-like Behavior in Mice
Agatha Meredydd Greenway, Michael W. Huebner, Jayme S. Waite, Harold C. Flinn, Brandon J. Rea, Toby C Buxton, Thomas L. Duong, Mengya Wang, Hailey L. Uemura, Nicholas O. Dorricott, Joseph O. Tutt, Kai Wang, Andrew F. Russo, Levi P. Sowers
This study shows that inhibiting the posterior thalamic nuclei in mice reduces CGRP-induced touch hypersensitivity and partially reduces light aversion, suggesting the PoT's role in migraine-like behaviors.
bioRxiv · Mar 3, 2025 · PreprintNeuroscience