Modulation of collagen-binding integrins affects fibroblast activation and inhibits fibrosis
Stefan Hamelmann, Fatemeh Derakhshandeh, Tom Wagner, Stephan F. W. Uebel, Barbara A. Steigenberger, Claire Minard‐Basquin, Sebastian Fabritz, Jutta Schröder–Braunstein, Guido H. Wabnitz, Inaam A. Nakchbandi
This study shows that modulating collagen-binding integrins can reduce fibrosis by inhibiting fibroblast activation in both liver and lung models, with differing mechanisms depending on the tissue.
bioRxiv · May 14, 2025 · PreprintCell Biology