Tomoki Kawaguchi

A bistable UV-sensitive opsin from a reef building coral showing a switchable and tunable regulation of Gs-signaling by different wavelengths of light

The paper characterizes and engineers a bistable cnidopsin from a coral that can switch between states using different light wavelengths, showing potential as an optogenetic tool for regulating Gs-signaling.

Molecular basis underlying specific interaction of mammalian melanopsins with an antagonist AA92593

This study identifies five amino acid residues in mammalian melanopsins responsible for the specific interaction with the antagonist AA92593.

Characterization and engineering of a blue-sensitive, Gi/o-biased, and bistable ciliary opsin from a fan worm

This paper characterizes a blue-sensitive, Gi/o-biased, and bistable ciliary opsin from a fan worm and explores its spectral and signaling properties through mutagenesis.