Phenotypic CRISPR screening identifies ZBTB10 as a novel regulator of human trophoblast differentiation
Meagan N. Esbin, Rituja Bhowmik, Hanqin Li, Andrew Cearlock, Jiayu Chen, Tomy Tran, Stephen A. McCartney, Ian A. Glass, Dirk F. Hockemeyer, Xavier Darzacq, Fyodor D. Urnov, Robert Tjian, Min Yang
The paper uses an arrayed CRISPR screen to identify ZBTB10 as a regulator of human trophoblast differentiation, showing its role in fusion and hormone secretion.
bioRxiv · Jul 1, 2026 · PreprintCell Biology