DNA gyrase in live bacteria forms liquid condensates through weak multivalent bonding of excess GyrB
Aisha H. Syeda, Katy Hollands, Lewis Frame, Jack W Shepherd, Alex L. Payne-Dwyer, Eleanor Goffee, Nicolas P. Burton, Aakash Basu, Agnes Noy, Tony Maxwell, Mark C. Leake
Live E. coli gyrase clusters hold excess GyrB (B:A 2.5:1), show hexanediol-sensitive liquid-like turnover, and docking suggests GyrB bridges heterotetramers.
bioRxiv · Aug 19, 2026 · PreprintBiophysics✦ In-depth digest