Tuo Yi

Progranulin deficiency induces lipid droplet accumulation in microglia via a STAT3-GPAT3 axis

This study shows that PGRN deficiency causes lipid droplet accumulation in microglia through the STAT3-GPAT3 axis, and identifies potential therapeutic strategies.

Elevated neuronal TAF15 expression leads to FTD-like phenotype

This study shows that elevated TAF15 expression in neurons causes oxidative stress, neurotoxicity, and FTD-like behaviors, which can be reversed by antioxidants.