Progranulin deficiency induces lipid droplet accumulation in microglia via a STAT3-GPAT3 axis
Jun Li, Yiyue Shi, Haoyuan Guan, Yifei Lü, Tuo Yi, Wei Li, Yini Wang, Yeting Guo, Bei Li, Caihong Zhu
This study shows that PGRN deficiency causes lipid droplet accumulation in microglia through the STAT3-GPAT3 axis, and identifies potential therapeutic strategies.
bioRxiv · Jan 20, 2026 · PreprintNeuroscience