Resolving a Guanine-Quadruplex Structure in the SARS-CoV-2 Genome through Circular Dichroism and Multiscale Molecular Modeling.
L. D'Anna, T. Miclot, E. Bignon, U. Perricone, G. Barone, A. Monari, A. Terenzi
The paper determines the structure of a guanine-quadruplex in SARS-CoV-2 RNA using molecular modeling and experimental validation, showing pyridostatin stabilizes it more than another G4 sequence.
bioRxiv · Apr 13, 2023Biophysics