Author

T. Miclot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 9 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Approach:biophysical modeling· 4 Approach:deep learning· 4 Assay:DNA methylation· 4 Organism:human· 4 Research Focus:protein folding & dynamics· 4 Research Focus:protein structure prediction· 3 Assay:structural biology· 3

Frequent Co-Authors

A. MONARI· 10 shared G. Barone· 10 shared A. Terenzi· 9 shared E. Bignon· 8 shared S. Grandemange· 6 shared C. Hognon· 5 shared L. D'Anna· 3 shared A. Spinello· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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10 shared papersBiophysics

A. MONARI

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10 papers

Recent·Most cited

Mechanism of the Covalent Inhibition of Human Transmembrane Protease Serine 2 as an Original Antiviral Strategy

A. Spinello, L. D'Anna, E. Bignon, T. Miclot, S. Grandemange, A. Terenzi, G. Barone, F. Barbault, A. MONARI

This study uses multiscale molecular modeling to investigate the mechanism of TMPRSS2 inhibition by Nafamostat, revealing its free-energy profile and structural dynamics.

bioRxiv · Apr 23, 2023Biophysics

Resolving a Guanine-Quadruplex Structure in the SARS-CoV-2 Genome through Circular Dichroism and Multiscale Molecular Modeling.

L. D'Anna, T. Miclot, E. Bignon, U. Perricone, G. Barone, A. Monari, A. Terenzi

The paper determines the structure of a guanine-quadruplex in SARS-CoV-2 RNA using molecular modeling and experimental validation, showing pyridostatin stabilizes it more than another G4 sequence.

bioRxiv · Apr 13, 2023Biophysics

Predicting the Three-dimensional Structure of the c-KIT Oncogene Promoter and the Dynamics of Strongly Coupled Guanine-Quadruplexes

E. Bignon, A. Spinello, T. Miclot, L. D'Anna, C. Ducani, S. Grandemange, G. Barone, A. MONARI, A. Terenzi

The paper predicts the 3D structure of the c-KIT promoter's G4s and shows how their coupling affects structure formation and drug discovery potential.

bioRxiv · Feb 23, 2023 · PreprintBiophysics

G-quadruplex recognition by DARPIns through epitope/paratope analogy

T. Miclot, E. Bignon, A. Terenzi, S. Grandemange, G. Barone, A. MONARI

This study investigates how DARPIns recognize G-quadruplexes through structural complementarity rather than sequence similarity, revealing a charged hollow region in DARPIns that hosts G4 structures.

bioRxiv · Jun 13, 2022Biophysics

Structure of the 5' untranslated region in SARS-CoV-2 genome and its specific recognition by innate immune system via the human oligoadenylate synthase 1

E. Bignon, T. Miclot, A. Terenzi, G. Barone, A. Monari

The paper reports the structure of SARS-CoV-2 5-UTR RNA complexed with OAS1, revealing how the SL1 region enhances specific interactions with the enzyme.

bioRxiv · Dec 10, 2021Biophysics

Never cared for what they do. High structural stability of Guanine-quadruplexes in presence of strand-break damages

T. Miclot, C. Hognon, E. Bignon, A. Terenzi, S. Grandemange, G. Barone, A. MONARI

The paper shows that guanine-quadruplexes remain structurally stable even with two strand breaks, unlike B-DNA, suggesting an evolutionary mechanism to mitigate ionizing radiation damage.

bioRxiv · Dec 1, 2021Biophysics

How fragile we are. Influence of STimulator of INterferon Genes, STING, variants on pathogen recognition and immune response efficiency

J. Morere, C. Hognon, T. Miclot, T. Jiang, E. Dumont, G. Barone, E. Bignon, A. MONARI

The paper uses molecular simulations and machine learning to analyze STING variants and explains how structural changes affect immune response efficiency.

bioRxiv · Jul 12, 2021Biochemistry

Structure and dynamics of RNA guanine quadruplexes in SARS-CoV-2 genome. Original strategies against emerging viruses

T. Miclot, C. Hognon, E. Bignon, A. Terenzi, M. Marazzi, G. Barone, A. MONARI

The paper calculates the first G4 structure of the RG-1 RNA sequence in SARS-CoV-2 genome using multiscale modeling and validates it with circular dichroism spectra, showing its stability and potential interaction with inhibitory ligands.

bioRxiv · May 20, 2021Biophysics

Forever Young: Structural Stability of Telomeric Guanine-Quadruplexes in Presence of Oxidative DNA Lesions.

T. Miclot, C. Corbier, A. Terenzi, C. Hognon, S. Grandemange, G. Barone, A. MONARI

The paper investigates the structural stability of telomeric G-quadruplexes in the presence of oxidative DNA lesions using experimental and computational methods.

bioRxiv · Nov 26, 2020Biophysics

Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses

C. Hognon, T. Miclot, C. Garcia Iriepa, A. France-Monerris, S. Grandemange, A. Terenzi, M. Marazzi, G. Barone, A. Monari

This study investigates how RNA guanine quadruplexes interact with the SARS Unique Domain using molecular dynamics simulations to understand their role in viral infection and potential therapeutic targeting.

bioRxiv · Apr 7, 2020Biophysics