Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex.
F. F. Scarante, V. D. Lopes, E. J. Fusse, M. A. Vicente, G. H. D. de Abreu, C. A. Sorgi, V. Nardini, P. H. C. Lirio, F. Gou, H.-C. Liu, J. E. C. Hallak, J. A. S. Crippa, L. H. Faccioli, K. U. Sales, F. S. Guimaraes, , A. C. Campos
This study shows that CBD reduces the latency of escitalopram's anti-stress effects in chronically stressed mice, involving NAPE-PLD in the prefrontal cortex and parvalbumin interneurons.
bioRxiv · Apr 23, 2021Pharmacology & Toxicology