Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
N. B. Punturi, S. Seker, V. Devarakonda, R. Kalra, C.-H. Chen, A. Mazumder, S.-Q. Li, T. Primeau, M. J. Ellis, S. M. Kavuri, S. Haricharan
This study shows that loss of MLH1, a mismatch repair gene, activates HER2 in ER+/HER2- breast cancer, making these cells sensitive to HER2 inhibitors.
bioRxiv · Jun 8, 2020Cancer Biology