C.-H. Chen

Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression

This study shows that mealtime affects the daily rhythm of nuclear O-GlcNAc proteome in mice, which regulates hepatic gene expression through interactions with phosphorylation.

A Sap Peptide Conserved across Flowering Plants Positively Regulates Lignin Biosynthesis, Biomass and Immunity

Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging

This study maps human bone marrow niches using single-cell transcriptomics and proteomic imaging, identifying distinct cellular environments and their roles in hematopoiesis and AML.

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

A chloroplast sulfate transporter modulates glutathione-mediated redox cycling to regulate cell division

The paper shows that a chloroplast sulfate transporter modulates glutathione levels, which in turn affects cell division in Chlamydomonas reinhardtii.

Aalbo1200: global genetic differentiation and variability of the mosquito Aedes albopictus

This study generates whole genome sequencing data from Aedes albopictus populations to analyze genetic differentiation and variability across tropical and temperate regions.

Spiral NeuroString: High-Density Soft Bioelectronic Fibers for Multimodal Sensing and Stimulation

This paper introduces Spiral NeuroString, high-density soft bioelectronic fibers for multimodal sensing and stimulation, demonstrating their use in GI motility mapping, serotonin sensing, and brain recordings.

High-throughput Automated Muropeptide Analysis (HAMA) Reveals Peptidoglycan Composition of Gut Microbial Cell Walls

The paper introduces HAMA, a high-throughput automated muropeptide analysis platform that identifies and quantifies muropeptide structures in bacterial peptidoglycan, revealing structural variations and correlations with cell stiffness.

ALDH2 dysfunction accelerates ESCC pathogenesis

This study shows that ALDH2 dysfunction accelerates ESCC pathogenesis by increasing CSCs, ROS, and DNA damage, and reduces response to cisplatin chemotherapy.

Mechanical transmission of Dengue Virus by Aedes aegypti may influence disease transmission dynamics during outbreaks

This study shows that Aedes aegypti mosquitoes can mechanically transmit Dengue Virus to mice immediately after biting infected mice, impacting outbreak dynamics and suggesting implications for vector control.

Reprogrammed Schwann cells organize into dynamic tracks that promote pancreatic cancer invasion

This study shows that Schwann cells activated by cancer cells form tracks that promote pancreatic cancer invasion through c-Jun-dependent mechanisms.

CAR-NK Cells Effectively Target the D614 and G614 SARS-CoV-2-infected Cells

This study demonstrates that S309-CAR-NK cells effectively target and kill SARS-CoV-2-infected cells, including the D614G mutant, outperforming CR3022-CAR-NK cells in vitro.

The neuronal GPCR OCTR-1 mediates temperature effects on longevity by regulating immune response genes in C. elegans

This study shows that OCTR-1 in C. elegans neurons regulates temperature-dependent longevity by modulating immune response genes.

The neuropeptide receptor NMUR-1 regulates the specificity of C. elegans innate immunity against pathogen infection

This study shows that NMUR-1 regulates C. elegans innate immunity specificity by modulating transcription factor activity and immune gene expression in response to pathogens.

Single-cell multi-omics reveals elevated plasticity and stem-cell-like blasts relevant to the poor prognosis of KMT2A-rearranged leukemia

This study uses single-cell multi-omics to identify lineage plasticity and stem-cell-like blasts in KMT2A-rearranged leukemia, linking these features to poor prognosis in infants.

Genomic, geographic and temporal distributions of SARS-CoV-2 mutations

This study analyzes the genomic, geographic, and temporal distribution of SARS-CoV-2 mutations using 1,932 genomes, identifying six phylogenetic clusters and a positive correlation between mutation count and case fatality.

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

Aerobic glycolysis supports hepatitis B virus biosynthesis through interaction between viral surface antigen and pyruvate kinase isoform M2

This paper shows that HBV uses aerobic glycolysis to support its biosynthesis by interacting with PKM2, and that restoring PKM2 activity can reduce viral production and oncogenesis.

Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer

This study shows that loss of MLH1, a mismatch repair gene, activates HER2 in ER+/HER2- breast cancer, making these cells sensitive to HER2 inhibitors.

Genome-wide CRISPR screens identify essential cell growth mediators in BRAF-inhibitor resistant melanoma

The paper identifies key regulators of BRAF inhibitor resistance in melanoma using CRISPR screens and integrates multi-omics data to reveal CDK6-dependent mechanisms.

Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers

This study identifies and characterizes noncoding mutations in pediatric cancers using a computational framework and experimental validation, revealing their role in deregulating cis-regulatory landscapes.

Broad Dengue Neutralization in Mosquitoes Expressing an Engineered Antibody

This paper develops genetically engineered Aedes aegypti mosquitoes expressing an engineered antibody that broadly neutralizes all four DENV serotypes, significantly reducing viral transmission.

Glucose intake hampers PKA-regulated HSP90 chaperone activity

The paper identifies Ids2 as a regulator of HSP90 chaperone activity, showing that glucose intake inhibits its function, linking nutrient sensing to proteostasis and longevity.