Cancer BiologybioRxiv
Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer
N. B. Punturi, S. Seker, V. Devarakonda…·S. Haricharan
This study shows that loss of MLH1, a mismatch repair gene, activates HER2 in ER+/HER2- breast cancer, making these cells sensitive to HER2 inhibitors.
DOI 10.1038/s41467-021-23271-0