V. Di Bartolo

Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids

This study uses a cancer-on-a-chip model to show that APC mutations impair T cell engagement and killing of tumor spheroids, despite normal migration and accumulation.

ERM-Dependent Assembly of T-Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli Prior to Activation

The paper shows that TCR complexes and co-stimulatory molecules are pre-assembled on microvilli via ERM-dependent mechanisms in resting T cells.