Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids
V. Bonnet, E. Maikranz, M. Madec, N. Vertti-Quintero, C. Cuche, M. Mastrogiovanni, A. Alcover, V. Di Bartolo, C. Baroud
This study uses a cancer-on-a-chip model to show that APC mutations impair T cell engagement and killing of tumor spheroids, despite normal migration and accumulation.
bioRxiv · Oct 17, 2023 · PreprintBioengineering