The yeast eIF2 kinase Gcn2 facilitates H2O2-mediated feedback inhibition of both protein synthesis and ER oxidative folding during recombinant protein production
V. Gast, K. Campbell, C. Picazo, M. K. M. Engqvist, V. Siewers, M. Molin
This study shows that Gcn2 kinase mediates H2O2 feedback inhibition of protein synthesis and ER oxidative folding in yeast during recombinant protein production, and its removal enhances -amylase production.
bioRxiv · Feb 3, 2021Bioengineering