Halogen-aromatic π-interactions modulate inhibitor residence time
C. Heroven, V. Georgi, G. K. Ganotra, P. E. Brennan, F. Wolfreys, R. C. Wade, A. E. Fernandez-Montalvan, A. Chaikuad, S. Knapp
The paper shows that halogen-aromatic π-interactions increase inhibitor residence time in kinase-inhibitor complexes, providing a strategy to improve drug efficacy and selectivity.
bioRxiv · Jan 29, 2018Biophysics