ORP5 AND ORP8 ORCHESTRATE LIPID DROPLET BIOGENESIS AND MAINTENANCE AT ER-MITOCHONDRIA CONTACT SITES
V. Guyard, V. F. Monteiro-Cardoso, M. Omrane, C. Sauvanet, A. Houcine, C. Boulogne, K. B. MBarek, N. Vitale, O. Facklaris, N. El Khallouki, A. R. Thiam, F. Giordano
This study identifies ORP5 and ORP8 as regulators of lipid droplet biogenesis at ER-mitochondria contact sites by controlling seipin recruitment and phosphatidic acid enrichment.
bioRxiv · Nov 11, 2021Cell Biology