Cell BiologybioRxiv
ORP5 AND ORP8 ORCHESTRATE LIPID DROPLET BIOGENESIS AND MAINTENANCE AT ER-MITOCHONDRIA CONTACT SITES
V. Guyard, V. F. Monteiro-Cardoso, M. Omrane…·F. Giordano
This study identifies ORP5 and ORP8 as regulators of lipid droplet biogenesis at ER-mitochondria contact sites by controlling seipin recruitment and phosphatidic acid enrichment.
DOI 10.1083/jcb.202112107