Cancer BiologybioRxiv
MAPK13 stabilization via m6A modification limits anti-cancer efficacy of rapamycin
J. Kim, Y. Chun, C. B. Ramirez…·G. Lee
This study shows that m6A modification of MAPK13 mRNA by the METTL3-METTL14-WTAP complex promotes its degradation, and rapamycin stabilizes MAPK13, which enhances anti-cancer effects when silenced.