C. Jang

Dietary isoleucine content defines the metabolic and molecular response to a Western diet

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell Renal Cell Carcinoma

This study shows HIF2α prevents GLS1 clustering in mitochondria, protecting ccRCC cells from glutamine deprivation, and suggests targeting GLS1 clustering could enhance HIF2 therapy.

A PTER-dependent pathway of taurine metabolism linked to energy balance

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK

This study shows that BT2, an inhibitor of BCKDK, reduces plasma tryptophan by displacing it from albumin, revealing an off-target effect on tryptophan metabolism.

Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues

The paper identifies inter-individual transcriptional correlations across metabolic tissues to infer signaling mechanisms, validating findings with known biological roles.

Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

This study shows that E-cadherin upregulates the serine synthesis pathway in breast cancer cells, supporting proliferation and metastasis by providing metabolic precursors and resistance to oxidative stress.

MAPK13 stabilization via m6A modification limits anti-cancer efficacy of rapamycin

This study shows that m6A modification of MAPK13 mRNA by the METTL3-METTL14-WTAP complex promotes its degradation, and rapamycin stabilizes MAPK13, which enhances anti-cancer effects when silenced.

ADOLESCENT EXPOSURE TO LOW-DOSE THC DISRUPTS ENERGY BALANCE AND ADIPOSE ORGAN HOMEOSTASIS IN ADULTHOOD

This study shows that adolescent exposure to low-dose THC leads to metabolic changes in adulthood, including reduced fat mass and adipose dysfunction.

Telomere dysfunction impairs intestinal differentiation andpredisposes to diet-induced colitis

This study shows that telomere shortening impairs intestinal differentiation, leading to barrier defects and diet-induced colitis through microbiome modulation and nutrient flux.

Interrogating Metabolic Interactions Between Skeletal Muscle and Liver Circadian Clocks In Vivo

The paper investigates the role of circadian clocks in liver and skeletal muscle in glucose metabolism, finding that inter-organ communication is necessary for systemic glucose homeostasis.

Photoperiod Sensitive Energy Sorghum Responses to Environmental and Nitrogen Variabilities

This study evaluates biomass yield and feedstock quality of photoperiod-sensitive sorghum hybrids under varying nitrogen inputs and environments, finding higher yields in temperate regions with lower nitrogen requirements.