G. Lee

Enhancement of Prednisolone efficacy and safety in Duchenne muscular dystrophy via neutrophil elastase inhibition

This paper shows that combining Alvelestat with Prednisolone improves muscle function and reduces side effects in a DMD mouse model.

Molecular tension authenticates apoptotic cells being phagocytosed

The paper identifies molecular tension between phosphatidylserine and its receptors as a signal determining phagocytosis of apoptotic cells.

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

Mosaic display of stable hemagglutinin monomers induces broad immune responses

This study develops a nanoparticle vaccine displaying conserved influenza HA epitopes, inducing broad neutralizing antibodies against multiple viral subtypes.

Induction of expansion of ex vivo NK cells using a new feeder cell built in Brazil. An extended flow cytometry evaluation of K562.mbIL21.4BBL

This paper develops a Brazilian feeder cell, K562.Clone1, which expands NK cells ex vivo more than 100-fold while preserving their antitumor activity.

Transcriptomic and epigenetic responses shed light on soybean resistance to Phytophthora sansomeana

This study examines transcriptomic and epigenetic responses in soybean lines resistant and susceptible to Phytophthora sansomeana, identifying key genes and regulatory mechanisms involved in defense.

Acceleration of HDL-mediated cellular cholesterol efflux alleviates periodontitis

This study shows hypercholesterolemia contributes to periodontitis and that fenofibrate reduces disease severity by enhancing HDL-mediated cholesterol efflux.

Validation of Dual Energy X-ray Absorptiometry for longitudinal quantification of tumor burden in a murine model of pancreatic ductal adenocarcinoma

This study compares bioluminescent imaging and dual energy X-ray absorptiometry for longitudinal tumor burden quantification in a murine PDAC model, finding DEXA superior for tracking tumor growth and correlating with final tumor mass.

A large effect fitness trade-off across environments is explained by a single mutation affecting cold acclimation

This study identifies a single mutation in CBF2 that causes a fitness trade-off by affecting cold acclimation in Arabidopsis thaliana across environments.

Distinct phases of cellular signaling revealed by time-resolved protein synthesis

This study uses a protein trans-splicing technology to reveal distinct phases of signaling in cancer-related proteins like BCR/ABL and DNAJB1/PRKACA.

The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix

This paper shows that the MRL mouse strain's extracellular matrix promotes muscle regeneration in muscular dystrophy by reducing fibrosis and enhancing myoblast growth.

Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

This study shows that E-cadherin upregulates the serine synthesis pathway in breast cancer cells, supporting proliferation and metastasis by providing metabolic precursors and resistance to oxidative stress.

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 that Exhibits Antiviral Efficacy in SARS-CoV-2 Infected African Green Monkeys

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis

This study uses single-cell and spatial multi-omics to show VDZ affects mononuclear phagocyte subsets and highlights gene expression patterns in UC.

Warmer water temperature and epizootic shell disease reduces diversity but increases cultivability of bacteria on the shells of American Lobster (Homarus americanus).

The study examines how water temperature and shell disease affect bacterial diversity and cultivability on American lobster shells.

MAPK13 stabilization via m6A modification limits anti-cancer efficacy of rapamycin

This study shows that m6A modification of MAPK13 mRNA by the METTL3-METTL14-WTAP complex promotes its degradation, and rapamycin stabilizes MAPK13, which enhances anti-cancer effects when silenced.

Hypoxic memory of tumor intrinsic type I interferon suppression promotes breast cancer metastasis

The paper shows hypoxia induces a long-lasting suppression of type I interferon and antigen presentation in breast cancer cells, enhancing metastasis and being reversible with HDACi and immunotherapy.

Mosaic receptor-binding domain nanoparticles induce protective immunity against SARS-CoV-2 challenges

This paper develops a mosaic nanoparticle vaccine, 6RBD-np, that induces full protection against SARS-CoV-2 wild type and Delta variants in mice.

Single-cell analysis of basal cell carcinoma reveals heat shock proteins promote tumor growth in response to WNT5A-mediated inflammatory signals

This study uses single-cell RNA sequencing to show heat shock proteins promote BCC growth in response to WNT5A-mediated inflammatory signals from the tumor microenvironment.

Stress Evaluation of Various Breeding Environments in Mouse

This study evaluates stress levels in mice across different breeding environments, finding lower cortisol and higher body weight in individually ventilated cages with environmental enrichment.

De-novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

This study identifies de-novo purine biosynthesis as a driver of chemoresistance in glioblastoma and shows that targeting it with Mycophenolate Mofetil can enhance TMZ efficacy.

Active Cytoskeletal Composites Display Emergent Tunable Contractility and Restructuring

This study combines experiments and modeling to show how actin, tubulin, and myosin composites exhibit tunable contractility and restructuring through their connectivity and motor density.

Infusion of CCR5 Gene-Edited T Cells Allows Immune Reconstitution, HIV Reservoir Decay, and Long-Term Virological Control

This study shows that infusing CCR5 gene-edited T cells improves immune function, reduces HIV reservoirs, and enables long-term viral control without ART.

Constitutively enhanced genome integrity maintenance and direct stress mitigation characterize transcriptome of extreme stress-adapted Arabidopsis halleri

This study compares transcriptomes of Arabidopsis halleri from highly contaminated and non-metalliferous soils, identifying stress adaptation mechanisms and gene expression changes.

Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics

This study investigates myosin-driven actin-microtubule networks and finds they exhibit self-organized contractile dynamics distinct from actin-only networks.

Broad-spectrum antiviral activity of 3D8, a nucleic acid-hydrolyzing single chain variable fragment (scFv), targeting SARS-CoV-2 and multiple coronaviruses in vitro

This study demonstrates that 3D8 scFv inhibits replication of SARS-CoV-2, HCoV-OC43, and PEDV in vitro through nucleic acid hydrolysis.

HIV-specific T-cell responses reflect substantive in vivo interactions with infected cells despite long-term therapy

The paper shows HIV-specific T-cell responses persist despite long-term ART, indicating ongoing recognition of infected cells and suggesting the reservoir is not fully immunologically silent.

A small molecule screen identified N-Acetyl-L-cysteine for promoting ex vivo growth of single circulating tumor cells

The paper identifies N-acetylcysteine (NAC) as a compound that promotes ex vivo growth of single circulating tumor cells by reducing oxidative stress.

The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro

This study identifies Alectinib as an FDA-approved drug that inhibits SARS-CoV-2 nucleocapsid phosphorylation and viral replication in vitro by targeting host kinases.

Human stem cell derived sensory neurons are positioned to support varicella zoster virus latency

This study investigates VZV latency and reactivation in human sensory neurons, finding they resist lytic infection but support latency and reactivation, mirroring in vivo conditions.