V. L. Lew

The circulatory physiopathology of human red blood cells investigated with a multiplatform model of cellular homeostasis. III. Senescence changes during the full circulatory lifespan

This paper investigates the mechanisms of red blood cell (RBC) senescence during their circulatory lifespan using a multiplatform model, finding that both quantal changes and pump decay are necessary for observed densification and density reversal patterns.

User guide to the red blood cell model (RCM), a multiplatform JAVA-based model of human red blood cell homeostasis

The paper introduces a JAVA-based model of human red blood cell homeostasis and demonstrates its use in studying dehydration and related pathophysiological processes.

The circulatory physiopathology of human red blood cells investigated with a multiplatform model of cellular homeostasis. II. Capillary transits and the role of PIEZO1

This paper uses a multiplatform red blood cell model to study capillary transit effects on RBC homeostasis, finding that PIEZO1 activation causes minimal, biphasic volume changes incompatible with a functional role in capillary flow.